Elevations of endogenous kynurenic acid produce spatial working memory deficits.

  title={Elevations of endogenous kynurenic acid produce spatial working memory deficits.},
  author={Amy C Chess and Michael K Simoni and Torey E Alling and David J Bucci},
  journal={Schizophrenia bulletin},
  volume={33 3},
Kynurenic acid (KYNA) is a tryptophan metabolite that is synthesized and released by astrocytes and acts as a competitive antagonist of the glycine site of N-methyl-D-aspartate receptors at high concentrations and as a noncompetitive antagonist of the alpha7-nicotinic acetylcholine receptor at low concentrations. The discovery of increased cortical KYNA levels in schizophrenia prompted the hypothesis that elevated KYNA concentration may underlie the working memory dysfunction observed in this… CONTINUE READING


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In Vitro and In Vivo Interactions Between Kynurenic Acid and The Nicotinic Allosteric Potentiating Ligand Galantamine: Clinical Relevance

  • C Lopes, EFR Pereira, H Wu, A Rassoulpour, R Schwarcz, EX. Albuquerque
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