Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes

@inproceedings{Sims2016ElevationsIT,
  title={Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes},
  author={Emily K Sims and Zunaira Z Chaudhry and Renecia A. Watkins and Farooq Syed and Janice S Blum and Fangqian Ouyang and Susan M. Perkins and Raghavendra G Mirmira and Jay M Sosenko and Linda A DiMeglio and Carmella Evans-Molina},
  booktitle={Diabetes care},
  year={2016}
}
OBJECTIVE We tested whether an elevation in the serum proinsulin-to-C-peptide ratio (PI:C), a biomarker of β-cell endoplasmic reticulum (ER) dysfunction, was associated with progression to type 1 diabetes. RESEARCH DESIGN AND METHODS Fasting total PI and C levels were measured in banked serum samples obtained from TrialNet Pathway to Prevention (PTP) participants, a cohort of autoantibody-positive relatives without diabetes of individuals with type 1 diabetes. Samples were obtained ∼12 months… CONTINUE READING