Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children.

@article{McDonald2016ElevationsIS,
  title={Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children.},
  author={Christine M. McDonald and Karim P Manji and Kerri B. Gosselin and Hao Quang Tran and Enju Liu and Rodrick R Kisenge and Said Aboud and Wafaie Wahib Fawzi and Andrew T. Gewirtz and Christopher P Duggan},
  journal={The American journal of clinical nutrition},
  year={2016},
  volume={103 6},
  pages={
          1548-54
        }
}
BACKGROUND Antibodies to LPS and flagellin have been described as indirect measures of increased gastrointestinal permeability and may be markers of environmental enteric dysfunction (EED), which is a condition associated with poor child growth. OBJECTIVE We assessed whether LPS- and flagellin-specific immunoglobulin (Ig) concentrations were associated with poor growth in young Tanzanian children at risk of EED. DESIGN Blood samples were obtained from 590 children at 6 wk, 6 mo, and 12 mo… CONTINUE READING
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