Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell mass.


A decrease in the expression of Islet-1 (Isl-1), an islet transcription factor, has been reported in several physiological settings of reduced β-cell function. Here, we investigate whether an increased level of Isl-1 in islet cells can enhance β-cell function and/or mass. We demonstrate that transgenic mice with Isl-1 overexpression display improved glucose… (More)
DOI: 10.4161/isl.19982


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