Elevation of total homocysteine levels in patients with Parkinson’s disease treated with duodenal levodopa/carbidopa gel

@article{Mller2011ElevationOT,
  title={Elevation of total homocysteine levels in patients with Parkinson’s disease treated with duodenal levodopa/carbidopa gel},
  author={T. M{\"u}ller and Constanze Jugel and R. Ehret and G. Ebersbach and Gunar Bengel and S. Muhlack and F. Klostermann},
  journal={Journal of Neural Transmission},
  year={2011},
  volume={118},
  pages={1329-1333}
}
Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine (thcys). We determined thcys-, LD- and 3-O-methyldopa (3-OMD) concentrations in 28 patients with Parkinson’s disease (PD) on a LD/CD duodenal gel treatment. We found a distinct thcys increase (29.52 ± 28.98 μmol/l [median ± SD]) above the 15 μmol/l threshold and a significant (R = 0.7) correlation between LD and 3-OMD. thcys ascent was observed in relation with the onset of atherosclerosis, non-motor symptoms and… Expand
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  • Medicine
  • Expert opinion on drug metabolism & toxicology
  • 2011
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2
3
4
5
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References

SHOWING 1-10 OF 25 REFERENCES
Homocysteine levels after acute levodopa intake in patients with Parkinson's disease
  • T. Müller, W. Kuhn
  • Medicine
  • Movement disorders : official journal of the Movement Disorder Society
  • 2009
Acute homocysteine rise after repeated levodopa application in patients with Parkinson's disease.
Levodopa and 3-OMD levels in Parkinson patients treated with Duodopa
Role of homocysteine in the treatment of Parkinson's disease
  • T. Müller
  • Medicine
  • Expert review of neurotherapeutics
  • 2008
Tolcapone decreases plasma levels of S-adenosyl-L-homocysteine and homocysteine in treated Parkinson’s disease patients
Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations.
Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease
...
1
2
3
...