Elevation of serum asymmetrical and symmetrical dimethylarginine in patients with advanced glaucoma.


PURPOSE Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are the dimethylated isomeric derivatives of the amino acid L-arginine. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS), while SDMA is a competitive inhibitor of cellular uptake of L-arginine, the substrate for NOS. As such, these metabolites are associated with… (More)
DOI: 10.1167/iovs.11-8420


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