Elevation of plasma viscosity induces sustained NO-mediated dilation in the hamster cremaster microcirculation in vivo

@article{Wit1997ElevationOP,
  title={Elevation of plasma viscosity induces sustained NO-mediated dilation in the hamster cremaster microcirculation in vivo},
  author={C. de Wit and Christian Sch{\"a}fer and Philipp von Bismarck and Steffen-Sebastian Bolz and Ulrich Pohl},
  journal={Pfl{\"u}gers Archiv},
  year={1997},
  volume={434},
  pages={354-361}
}
  • C. de Wit, Christian Schäfer, +2 authors Ulrich Pohl
  • Published in Pflügers Archiv 1997
  • DOI:10.1007/s004240050408
Abstract We studied whether a flow-independent increase of luminal wall shear stress (WSS) could dilate hamster arterioles in vivo and which endothelial mediators are potentially involved. To this end the plasma viscosity was elevated by exchanging blood for dextran-erythrocyte solution thereby augmenting WSS. Diameters of small and large arterioles as well as red blood cell velocities were measured before and after exchange of blood for solutions of identical haematocrit containing either high… CONTINUE READING
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