Elevation of intrarenal adenosine by maleic acid decreases GFR and renin release.

@article{Arend1986ElevationOI,
  title={Elevation of intrarenal adenosine by maleic acid decreases GFR and renin release.},
  author={Lois J. Arend and Carl I. Thompson and M A Brandt and William S. Spielman},
  journal={Kidney international},
  year={1986},
  volume={30 5},
  pages={656-61}
}
Maleic acid administration produces a defect in tubular reabsorption resembling that seen in the Fanconi syndrome and also causes a decrease in glomerular filtration rate (GFR). The mechanism by which maleic acid alters renal function is uncertain, though the tubular defect is known to be associated with decreased ATP levels. Because of this alteration in nucleotide metabolism the present study was undertaken to determine the role of elevated endogenous adenosine in mediating the maleic acid… CONTINUE READING

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