Elevation of interleukin-18 in chronic hepatitis C: implications for hepatitis C virus pathogenesis.

@article{Sharma2009ElevationOI,
  title={Elevation of interleukin-18 in chronic hepatitis C: implications for hepatitis C virus pathogenesis.},
  author={Arpita Sharma and Anuradha Chakraborti and Ashim Das and Radha Krishan Dhiman and Yogesh Chawla},
  journal={Immunology},
  year={2009},
  volume={128 1 Suppl},
  pages={e514-22}
}
The outcome of hepatitis C virus (HCV) infection is determined by the interplay between the virus and the host immune response. Interleukin (IL)-18, an interferon-gamma-inducing factor, plays a critical role in the T helper type 1 (Th1) response required for host defence against viruses, and antibodies to IL-18 have been found to prevent liver damage in a murine model. The present study was conducted to investigate the possible role of IL-18 in the pathogenesis and persistence of HCV. IL-18… CONTINUE READING
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