Elevation of hippocampal MMP-3 expression and activity during trauma-induced synaptogenesis.

@article{Kim2005ElevationOH,
  title={Elevation of hippocampal MMP-3 expression and activity during trauma-induced synaptogenesis.},
  author={Hee Jung Kim and Helen L Fillmore and Thomas Reeves and Linda L. Phillips},
  journal={Experimental neurology},
  year={2005},
  volume={192 1},
  pages={60-72}
}
The matrix metalloproteinase (MMP) enzyme family contributes to the regulation of a variety of brain extracellular matrix molecules. In order to assess their role in synaptic plasticity following traumatic brain injury (TBI), we compared expression of stromelysin-1 (MMP-3) protein and mRNA in two rodent models of TBI exhibiting different levels of recovery: adaptive synaptic plasticity following central fluid percussion injury and maladaptive synaptic plasticity generated by combined TBI and… CONTINUE READING

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