Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects.

@article{Tripathy2003ElevationOF,
  title={Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects.},
  author={Devjit Tripathy and Priya Ranjan Mohanty and Sandeep Singh Dhindsa and Tufail Syed and Husam Ghanim and Ahmad Aljada and Paresh Dandona},
  journal={Diabetes},
  year={2003},
  volume={52 12},
  pages={2882-7}
}
To test the possible acute proinflammatory effects of fatty acids, we induced an increase in plasma free fatty acid (FFA) concentrations after a lipid and heparin infusion for 4 h in 10 healthy subjects. We determined the nuclear factor-kappaB (NF-kappaB) binding activity in mononuclear cells (MNCs), the p65 subunit of NF-kappaB, reactive oxygen species (ROS) generation by MNC, and polymorphonuclear leukocytes (PMN). Brachial artery reactivity, using postischemic flow-mediated dilation, was… CONTINUE READING

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