Elevation of extracellular potassium facilitates the induction of hippocampal long-term potentiation.

@article{Ballyk1992ElevationOE,
  title={Elevation of extracellular potassium facilitates the induction of hippocampal long-term potentiation.},
  author={Barbara A. Ballyk and Joanne W. Goh},
  journal={Journal of neuroscience research},
  year={1992},
  volume={33 4},
  pages={598-604}
}
Hippocampal long-term potentiation (LTP) is widely believed to be a cellular substrate for learning and memory. A likely physiological stimulus for initiating LTP is repetitive neuronal activity, which also results in K+ accumulation extracellularly. Therefore, the involvement of elevated extracellular K+ concentrations in the induction of LTP of the stratum radiatum-CA1 neuronal synapse was investigated in the hippocampal slice preparation. Increasing the K+ content in extracellular perfusing… CONTINUE READING