Elevation of extracellular adenosine induces radioprotective effects in mice.

  title={Elevation of extracellular adenosine induces radioprotective effects in mice.},
  author={Milan Posp{\'i}{\vs}il and Michal Hofer and Jarom{\'i}ra Net{\'i}kov{\'a} and Iva Pipalov{\'a} and Anton{\'i}n Vacek and A. Barton{\'i}{\vc}kov{\'a} and Karel Volenec},
  journal={Radiation research},
  volume={134 3},
The radioprotective effectiveness of the elevation of extracellular adenosine induced in mice by the combined administration of dipyridamole, a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate, a soluble adenosine pro-drug, was evaluated. Based on survival studies, endogenous hemopoietic spleen colony formation, and the postirradiation behavior of bone marrow granulocyte-macrophage colony-forming cells (GM-CFC), it was demonstrated that the combined administration… CONTINUE READING
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