Elevation of dopamine D2 receptors in schizophrenia is underestimated by radioactive raclopride.

@article{Seeman1990ElevationOD,
  title={Elevation of dopamine D2 receptors in schizophrenia is underestimated by radioactive raclopride.},
  author={P. Seeman and H. Niznik and H. Guan},
  journal={Archives of general psychiatry},
  year={1990},
  volume={47 12},
  pages={
          1170-2
        }
}
  • P. Seeman, H. Niznik, H. Guan
  • Published 1990
  • Psychology, Medicine
  • Archives of general psychiatry
  • To the Editor.— In schizophrenia, the brain reveals elevated densities of dopamine D 2 receptors whether or not the patients have received neuroleptic medications. 1-3 In addition, the left putamen in schizophrenia shows D 2 to be elevated by 2.8 pmol/mL, significantly different from the right side, but nonsignificantly elevated by 3.2 pmol/mL compared with controls. 4 It has been puzzling that these unilateral elevations of 2.8 to 3.2 pmol/mL, seen with [ 11 C]raclopride, are less than the… CONTINUE READING
    60 Citations

    Topics from this paper

    Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.
    • 934
    • PDF
    Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans
    • 260
    • PDF

    References

    SHOWING 1-10 OF 12 REFERENCES
    Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum.
    • 78
    • PDF
    Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain.
    • 174
    • PDF
    Dopamine receptors and transporters in Parkinson's disease and schizophrenia
    • P. Seeman, H. Niznik
    • Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 1990
    • 273
    Human brain dopamine receptors in children and aging adults
    • 385
    Kinetic properties of the accumulation of 3H-raclopride in the mouse brain in vivo
    • 43