Elevation of dopamine D2 receptors in schizophrenia is underestimated by radioactive raclopride.

  title={Elevation of dopamine D2 receptors in schizophrenia is underestimated by radioactive raclopride.},
  author={P. Seeman and H. Niznik and H. Guan},
  journal={Archives of general psychiatry},
  volume={47 12},
  • P. Seeman, H. Niznik, H. Guan
  • Published 1990
  • Psychology, Medicine
  • Archives of general psychiatry
  • To the Editor.— In schizophrenia, the brain reveals elevated densities of dopamine D 2 receptors whether or not the patients have received neuroleptic medications. 1-3 In addition, the left putamen in schizophrenia shows D 2 to be elevated by 2.8 pmol/mL, significantly different from the right side, but nonsignificantly elevated by 3.2 pmol/mL compared with controls. 4 It has been puzzling that these unilateral elevations of 2.8 to 3.2 pmol/mL, seen with [ 11 C]raclopride, are less than the… CONTINUE READING
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