Elevation of cytotoxic lymphocyte gene expression is predictive of islet allograft rejection in nonhuman primates.

@article{Han2002ElevationOC,
  title={Elevation of cytotoxic lymphocyte gene expression is predictive of islet allograft rejection in nonhuman primates.},
  author={Dongmei Han and Xiumin Xu and Ricardo Luis Pastori and Camillo Ricordi and Norma Sue Kenyon},
  journal={Diabetes},
  year={2002},
  volume={51 3},
  pages={562-6}
}
Hyperglycemia and increased insulin requirements are indicators of ongoing islet allograft rejection, but there are no methods to predict or confirm rejection. Elevation of cytotoxic lymphocyte (CL) gene expression in peripheral blood (PB) has been correlated with renal allograft rejection in humans, but no published study has assessed the utility of monitoring these markers as predictors of rejection before the onset of clinical symptoms. We have established quantitative real-time PCR methods… CONTINUE READING

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