Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons.

@article{Chaves1997ElevationOC,
  title={Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons.},
  author={Elena I Posse de Chaves and Matthieu Bussi{\`e}re and Dennis E. Vance and Robert B. Campenot and Jean E. Vance},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 5},
  pages={3028-35}
}
Sphingolipids are abundant constituents of neuronal membranes and have been implicated in intracellular signaling. We show that two analogs of glycosphingolipid biosynthetic intermediates, fumonisin B1 (which inhibits dihydroceramide synthesis) and DL-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) (which inhibits glucosylceramide synthesis) decrease glycosphingolipid synthesis in rat sympathetic neurons. Although both fumonisin and PPMP inhibit glycosphingolipid synthesis, these… CONTINUE READING

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