Elevation of cAMP in human platelets inhibits thrombin- but not collagen-induced tyrosine phosphorylation.

Both thrombin and collagen induced the phosphorylation of tyrosine in numerous proteins in platelets, with collagen causing the phosphorylation of an additional 40 kDa protein. Thrombin-induced phosphorylation was markedly inhibited when cAMP was elevated with iloprost. Iloprost or the combination of iloprost, inhibitors of positive feedback and… CONTINUE READING