Elevation of brain-type creatine kinase in serum from patients with carcinoma.

@article{Coolen1979ElevationOB,
  title={Elevation of brain-type creatine kinase in serum from patients with carcinoma.},
  author={R B Coolen and D. A. Pragay and Jerome S Nosanchuk and Russell Belding},
  journal={Cancer},
  year={1979},
  volume={44 4},
  pages={1414-8}
}
The brain isoenzyme of creatine kinase (CK BB) occurs in trace amounts in normal serum and is moderately increased in only a small number of non-oncological conditions. Although many tissues and tumors contain CK BB, we observed serum elevations only in certain carcinomas. Eleven patients with tissue-proven small cell anaplastic carcinoma (SCAC) of the lung had striking elevations of serum CK BB and no evidence of central nervous system (CNS) metastases. Significant increases were also observed… CONTINUE READING