Elevation of brain prostaglandin E2 levels in rodents by delta 1-tetrahydrocannabinol.


An isotopic dilution procedure using specific prostaglandin E2 (PGE2) brain receptors was utilized to determine the changes in brain PGE2 levels subsequent to drug exposure. Delta-1-tetrahydrocannabinol (delta 1-THC) stimulated PGE2 synthesis resulting in increased brain concentrations when compared with vehicle treated rats and mice. Indomethacin markedly inhibited the delta 1-THC elevated rise in PGE2 levels presumably by inhibition of prostaglandin synthetase. The delta 1-THC-induced increase in PGE2 brain levels was also suppressed by i.v. administered rabbit PGE2-antiserum. This suggests that one of the sites of delta 1-THC action is extracerebral and from here a portion of the released prostaglandins are transported to the brain. These results add further support to previous data that delta 1-THC given orally results in an increase in brain PGE2 levels.

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@article{Hunter1991ElevationOB, title={Elevation of brain prostaglandin E2 levels in rodents by delta 1-tetrahydrocannabinol.}, author={Sheila Hunter and Corinne Audette and Sumner H. Burstein}, journal={Prostaglandins, leukotrienes, and essential fatty acids}, year={1991}, volume={43 3}, pages={185-90} }