Elevation of brain prostaglandin E2 levels in rodents by delta 1-tetrahydrocannabinol.

@article{Hunter1991ElevationOB,
  title={Elevation of brain prostaglandin E2 levels in rodents by delta 1-tetrahydrocannabinol.},
  author={Sheila A. Hunter and C A Audette and Sumner H Burstein},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1991},
  volume={43 3},
  pages={185-90}
}
An isotopic dilution procedure using specific prostaglandin E2 (PGE2) brain receptors was utilized to determine the changes in brain PGE2 levels subsequent to drug exposure. Delta-1-tetrahydrocannabinol (delta 1-THC) stimulated PGE2 synthesis resulting in increased brain concentrations when compared with vehicle treated rats and mice. Indomethacin markedly… CONTINUE READING