Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats

@article{Devall2015ElevationOB,
  title={Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats},
  author={A. Devall and J. M. Santos and J. Fry and J. Honour and M. Brand{\~a}o and T. Lovick},
  journal={European Neuropsychopharmacology},
  year={2015},
  volume={25},
  pages={113-123}
}
Withdrawal from long-term dosing with exogenous progesterone precipitates increased anxiety-linked changes in behavior in animal models due to the abrupt decrease in brain concentration of allopregnanolone (ALLO), a neuroactive metabolite of progesterone. We show that a withdrawal-like effect also occurs during the late diestrus phase (LD) of the natural ovarian cycle in rats, when plasma progesterone and ALLO are declining but estrogen secretion maintains a stable low level. This effect at LD… Expand
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats
TLDR
It is proposed that insensitivity to diazepam in late diestrus is due to increased expression of benzodiazepine insensitive α4 subunit-containing gamma-aminobutyric acid A (GABAA) receptors triggered by a sharp decrease in brain allopregnanolone concentration. Expand
Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats
TLDR
The light switch-off and isolation restraint-induced USV tests evoke unconditioned adverse emotional responses that are ethologically relevant and sensitive to oestrous cycle stage and may have potential to alleviate development of adverse premenstrual symptoms in women. Expand
Allopregnanolone reversion of estrogen and progesterone memory impairment: interplay with serotonin release
TLDR
The results suggest that allopregnanolone memory improvement could be mediated, at least in part, through modulation of the hippocampal serotonergic system reactivity. Expand
The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins
TLDR
It is demonstrated that there is a consistent decrease in allopregnanolone levels in limbic brain areas in rodents submitted to stress-induced models of depression, such as social isolation and chronic unpredictable stress, which reduces depressive-like behaviors in models such as the forced swim test. Expand
Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
TLDR
Repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction. Expand
Allopregnanolone in premenstrual dysphoric disorder (PMDD): Evidence for dysregulated sensitivity to GABA-A receptor modulating neuroactive steroids across the menstrual cycle
TLDR
The literature supports the hypothesis that PMDD pathophysiology is rooted in impaired GABAA-R response to dynamic ALLO fluctuations across the menstrual cycle, manifesting in affective symptoms and poor regulation of physiologic stress response. Expand
Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models
TLDR
Paeonol is a potential therapeutic compound for PMS/PMDD; it is a drug option that helps establish dosage guidance for treatment of this condition and demonstrates excellent effects in improving anxiety, particularly irritable emotional behaviour. Expand
5-HT1A receptors of the prelimbic cortex mediate the hormonal impact on learned fear expression in high-anxious female rats
TLDR
Fear intensity is associated with hormonal decay, being more accentuated during the estrus phase and negatively correlated with the expression of potentiated startle, and future studies on this subject need to take into account the dissociation between low- and high-responsive females to understand how hormones affect emotional behavior. Expand
Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age
TLDR
Findings suggest a link between the typical psychological well-being experienced in the follicular phase when allopregnanolone levels are low and higher SERT in the prefrontal cortex, a region for higher cognitive functions and top-down regulation of emotions. Expand
Effect of Estrous Cycle on Behavior of Females in Rodent Tests of Anxiety
Anxiety disorders are more prevalent in women than in men. In women the menstrual cycle introduces another variable; indeed, some conditions e.g., premenstrual syndrome, are menstrual cycle specific.Expand
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