Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats
@article{Devall2015ElevationOB, title={Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats}, author={Adam J Devall and J{\'u}lia Maria dos Santos and Jonathan P Fry and John W Honour and M L Brand{\~a}o and Thelma Anderson Lovick}, journal={European Neuropsychopharmacology}, year={2015}, volume={25}, pages={113-123} }
32 Citations
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats
- Biology, PsychologyJournal of psychopharmacology
- 2016
It is proposed that insensitivity to diazepam in late diestrus is due to increased expression of benzodiazepine insensitive α4 subunit-containing gamma-aminobutyric acid A (GABAA) receptors triggered by a sharp decrease in brain allopregnanolone concentration.
Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: Involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray
- Biology, PsychologyJournal of psychopharmacology
- 2021
Overall, females were more responsive to acute hypoxia than males and this is clearer in late diestrus phase, and low-dose fluoxetine administered in the premenstrual phase deserves further attention for management of panic disorders in women.
Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats
- Biology, PsychologyJournal of psychopharmacology
- 2019
The light switch-off and isolation restraint-induced USV tests evoke unconditioned adverse emotional responses that are ethologically relevant and sensitive to oestrous cycle stage and may have potential to alleviate development of adverse premenstrual symptoms in women.
Allopregnanolone reversion of estrogen and progesterone memory impairment: interplay with serotonin release
- Biology, PsychologyJournal of Neural Transmission
- 2019
The results suggest that allopregnanolone memory improvement could be mediated, at least in part, through modulation of the hippocampal serotonergic system reactivity.
The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins
- Biology, PsychologyNeurobiology of Stress
- 2020
Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
- Biology, PsychologyScientific Reports
- 2017
Repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction.
Allopregnanolone in premenstrual dysphoric disorder (PMDD): Evidence for dysregulated sensitivity to GABA-A receptor modulating neuroactive steroids across the menstrual cycle
- Biology, PsychologyNeurobiology of Stress
- 2020
Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models
- Biology, PsychologyFrontiers in Psychiatry
- 2020
Paeonol is a potential therapeutic compound for PMS/PMDD; it is a drug option that helps establish dosage guidance for treatment of this condition and demonstrates excellent effects in improving anxiety, particularly irritable emotional behaviour.
5-HT1A receptors of the prelimbic cortex mediate the hormonal impact on learned fear expression in high-anxious female rats
- Biology, PsychologyHormones and Behavior
- 2016
Panic‐like responses of female Wistar rats confronted by Bothrops alternatus pit vipers, or exposure to acute hypoxia: Effect of oestrous cycle
- Psychology, BiologyThe European journal of neuroscience
- 2021
It is revealed that females respond in a qualitatively similar manner to males during exposure to naturally occurring threatening stimuli, but the responses of females is oestrous cycle dependent with a significant exacerbation of panic‐like behaviour in the late dioestrus phase.
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