Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats

@article{Devall2015ElevationOB,
  title={Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats},
  author={Adam J Devall and J{\'u}lia Maria dos Santos and Jonathan P Fry and John W Honour and M L Brand{\~a}o and Thelma Anderson Lovick},
  journal={European Neuropsychopharmacology},
  year={2015},
  volume={25},
  pages={113-123}
}
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats
TLDR
It is proposed that insensitivity to diazepam in late diestrus is due to increased expression of benzodiazepine insensitive α4 subunit-containing gamma-aminobutyric acid A (GABAA) receptors triggered by a sharp decrease in brain allopregnanolone concentration.
Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: Involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray
TLDR
Overall, females were more responsive to acute hypoxia than males and this is clearer in late diestrus phase, and low-dose fluoxetine administered in the premenstrual phase deserves further attention for management of panic disorders in women.
Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats
TLDR
The light switch-off and isolation restraint-induced USV tests evoke unconditioned adverse emotional responses that are ethologically relevant and sensitive to oestrous cycle stage and may have potential to alleviate development of adverse premenstrual symptoms in women.
Allopregnanolone reversion of estrogen and progesterone memory impairment: interplay with serotonin release
TLDR
The results suggest that allopregnanolone memory improvement could be mediated, at least in part, through modulation of the hippocampal serotonergic system reactivity.
Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
TLDR
Repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction.
Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models
TLDR
Paeonol is a potential therapeutic compound for PMS/PMDD; it is a drug option that helps establish dosage guidance for treatment of this condition and demonstrates excellent effects in improving anxiety, particularly irritable emotional behaviour.
Panic‐like responses of female Wistar rats confronted by Bothrops alternatus pit vipers, or exposure to acute hypoxia: Effect of oestrous cycle
TLDR
It is revealed that females respond in a qualitatively similar manner to males during exposure to naturally occurring threatening stimuli, but the responses of females is oestrous cycle dependent with a significant exacerbation of panic‐like behaviour in the late dioestrus phase.
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The pseudopregnancy paradigm may be a useful model for periods of endogenous 3alpha,5alpha-THP withdrawal such as premenstrual syndrome and postpartum or postmenopausal dysphoria, when increased emotional lability and BDZ insensitivity have been reported.
Withdrawal from 3α-OH-5α-Pregnan-20-One Using a Pseudopregnancy Model Alters the Kinetics of Hippocampal GABAA-Gated Current and Increases the GABAAReceptor α4 Subunit in Association with Increased Anxiety
TLDR
The pseudopregnancy paradigm may be a useful model for periods of endogenous 3α,5α-THP withdrawal such as premenstrual syndrome and postpartum or postmenopausal dysphoria, when increased emotional lability and BDZ insensitivity have been reported.
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