Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expression

@inproceedings{Teo2017ElevationOA,
  title={Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expression},
  author={Ziqiang Teo and Ming Keat Sng and Jeremy Soon Kiat Chan and Maegan Miang Kee Lim and Y Li and Li Li and Terri Phua and Ji Hyun Lee and Zhen Wei Tan and Ping Zhu and Nguan Soon Tan},
  booktitle={Oncogene},
  year={2017}
}
Metastatic cancer cells acquire energy-intensive processes including increased invasiveness and chemoresistance. However, how the energy demand is met and the molecular drivers that coordinate an increase in cellular metabolic activity to drive epithelial–mesenchymal transition (EMT), the first step of metastasis, remain unclear. Using different in vitro and in vivo EMT models with clinical patient’s samples, we showed that EMT is an energy-demanding process fueled by glucose metabolism-derived… CONTINUE READING
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