Elevation of acetylcholine levels in striatum of rat brain by LY163502, trans−(−)−5,5a,6,7,8,9a,10-octahydro-6-propylpyrimido〈4,5−g〉quinolin-2- amine dihydrochloride, a potent and stereospecific dopamine (D2) agonist

@inproceedings{Bymaster1986ElevationOA,
  title={Elevation of acetylcholine levels in striatum of rat brain by LY163502, trans−(−)−5,5a,6,7,8,9a,10-octahydro-6-propylpyrimido〈4,5−g〉quinolin-2- amine dihydrochloride, a potent and stereospecific dopamine (D2) agonist},
  author={Frank P. Bymaster and Leroy R. Reid and Cynthia L. Nichols and Edmund C. Kornfeld and David Taiwai Wong},
  year={1986}
}
Abstract LY163502, a partial ergoline and a trans-levorotatory enantiomer, does not stimulate adenylate cyclase in striatal membranes but inhibits 50% binding of 3 H-apomorphine, 3 H-pergolide and 3 H-spiperone at 10, 13 and 151 nM (IC 50 ), respectively. The racemic mixture (LY137157) is less effective, with 3, 2.7 and 1.4 times higher IC 50 values, respectively, whereas the dextrorotatory isomer (LY175877) is inactive. LY163502 inhibits binding of 3 H-clonidine with an IC 50 value of 2600 nM… CONTINUE READING

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