Elevation of Urinary Norepinephrine/Cortisol Ratio in Posttraumatic Stress Disorder

  title={Elevation of Urinary Norepinephrine/Cortisol Ratio in Posttraumatic Stress Disorder},
  author={J. Mason and E. Giller and T. Kosten and L. Harkness},
  journal={The Journal of Nervous and Mental Disease},
We have previously reported the unusual combination of low urinary free cortisol levels with high urinary norepinephrine excretion in posttraumatic stress disorder (PTSD) patients in comparison with four other patient groups: major depressive disorder, endogenous type; bipolar I, manic; paranoid schizophrenia; undifferentiated schizophrenia. Cortisol levels alone did not distinguish PTSD from paranoid schizophrenia patients and norepinephrine levels alone did not distinguish PTSD from bipolar I… Expand
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The norepinephrine-to-cortisol ratio was not significantly elevated in the PTSD+ diagnosed women in contrast to the findings reported for male PTSD patients, suggesting an important gender difference, an interaction between gender and age at onset of the traumatic experience, or physiological variation related to phase of the disorder. Expand
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The preliminary findings indicate that alexithymia is associated with an increased noradrenergic activity and a decreased basal activity of the hypothalamic-pituitary-adrenal (HPA) axis among men. Expand
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Dysregulation of the stress system, including the hypothalamic-pituitary-adrenal (HPA) axis and the locus caeruleus/norepinephrine-sympathetic nervous system (SNS), is involved in the pathophysiologyExpand
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Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: findings and clinical implications.
  • J. Boscarino
  • Psychology, Medicine
  • Journal of consulting and clinical psychology
  • 1996
Morning serum cortisol was compared among Vietnam "theater" veterans and Vietnam "era" veterans to test the hypothesis that individuals with posttraumatic stress disorder experience neuroendocrine system alterations, resulting in significantly lower plasma cortisol. Expand