Elevation of Tumor Necrosis Factor Alpha in Dorsal Root Ganglia and Spinal Cord is Associated with Neuroimmune Modulation of Pain in an Animal Model of Multiple Sclerosis

@article{Begum2013ElevationOT,
  title={Elevation of Tumor Necrosis Factor Alpha in Dorsal Root Ganglia and Spinal Cord is Associated with Neuroimmune Modulation of Pain in an Animal Model of Multiple Sclerosis},
  author={Farhana Begum and Wenjun Zhu and Claudia Cortes and Brain MacNeil and Michael Namaka},
  journal={Journal of Neuroimmune Pharmacology},
  year={2013},
  volume={8},
  pages={677-690}
}
Neuropathic pain (NPP) is a frequently reported symptom described by 50–80% of multiple sclerosis (MS) patients. Although Th1 cell activation is known to drive the pathology of MS, this critical step has also been suggested to be involved in the neuroimmune induction of NPP. The release of pain inducing inflammatory cytokines such as tumour necrosis factor alpha (TNFα) from activated Th1 cells may have key implications in the development of MS-induced pain. We hypothesize that immune mediated… CONTINUE READING
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