Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain.

@article{Saito2012ElevationOG,
  title={Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain.},
  author={Mitsuo Saito and Goutam Chakraborty and Relish Shah and Rui-Fen Mao and Asok Kumar and Dun-Sheng Yang and Kostantin Dobrenis},
  journal={Journal of neurochemistry},
  year={2012},
  volume={121 4},
  pages={649-61}
}
GM2 ganglioside in the brain increased during ethanol-induced acute apoptotic neurodegeneration in 7-day-old mice. A small but a significant increase observed 2 h after ethanol exposure was followed by a marked increase around 24 h. Subcellular fractionation of the brain 24 h after ethanol treatment indicated that GM2 increased in synaptic and non-synaptic mitochondrial fractions as well as in a lysosome-enriched fraction characteristic to the ethanol-exposed brain. Immunohistochemical staining… CONTINUE READING
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