Elevation of Extracellular Ca2+ Induces Store-Operated Calcium Entry via Calcium-Sensing Receptors: A Pathway Contributes to the Proliferation of Osteoblasts

@inproceedings{Hu2014ElevationOE,
  title={Elevation of Extracellular Ca2+ Induces Store-Operated Calcium Entry via Calcium-Sensing Receptors: A Pathway Contributes to the Proliferation of Osteoblasts},
  author={Fen Hu and Leiting Pan and Kai Zhang and Fulin Xing and Xinyu Wang and Imshik Lee and Xinzheng Zhang and Jingjun Xu and Jo{\~a}o Costa-Rodrigues},
  booktitle={PloS one},
  year={2014}
}
AIMS The local concentration of extracellular Ca(2+) ([Ca(2+)]o) in bone microenvironment is accumulated during bone remodeling. In the present study we investigated whether elevating [Ca(2+)]o induced store-operated calcium entry (SOCE) in primary rat calvarial osteoblasts and further examined the contribution of elevating [Ca(2+)]o to osteoblastic proliferation. METHODS Cytosolic Ca(2+) concentration ([Ca(2+)]c) of primary cultured rat osteoblasts was detected by fluorescence imaging using… CONTINUE READING

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