Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

@inproceedings{Gaunt2016ElevationOC,
  title={Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection},
  author={Eleanor R. Gaunt and Helen M. Wise and Huayu Zhang and Lian N Lee and Nicky J. Atkinson and Marlynne Quigg Nicol and Andrew J Highton and Paul Klenerman and Philippa M. Beard and Bernadette M. Dutia and Paul Digard and Peter Simmonds},
  booktitle={eLife},
  year={2016}
}
Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus (IAV) with maximised frequencies of these dinucleotides in segment 5 showed comparable attenuation in cell culture compared to unmodified virus and a permuted control (CDLR). Attenuation was also manifested in vivo, with 10-100 fold reduced viral loads in lungs of mice infected with 200PFU of CpG… CONTINUE READING
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