Elevation of CSF Tumor Necrosis Factor α Levels in New Daily Persistent Headache and Treatment Refractory Chronic Migraine

@article{Rozen2007ElevationOC,
  title={Elevation of CSF Tumor Necrosis Factor $\alpha$ Levels in New Daily Persistent Headache and Treatment Refractory Chronic Migraine},
  author={Todd D. Rozen and Sahar Z. Swidan},
  journal={Headache: The Journal of Head and Face Pain},
  year={2007},
  volume={47}
}
  • T. Rozen, S. Swidan
  • Published 1 July 2007
  • Medicine
  • Headache: The Journal of Head and Face Pain
Objective.—To determine if patients with new daily persistent headache (NDPH) have elevated levels of tumor necrosis factor α (TNF α) in the CSF. 
Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine
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A patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine, hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology.
Triggering Events and New Daily Persistent Headache: Age and Gender Differences and Insights on Pathogenesis–A Clinic‐Based Study
To define what are the age and gender differences for new daily persistent headache (NDPH) triggering events and how this may relate to the pathogenesis of NDPH. To describe several new triggering
Headache in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Narrative Review
To summarize available literature regarding headache as a manifestation of coronaviruses and to describe potential underlying mechanisms.
Long‐Term Outcomes of Occipital Nerve Stimulation for New Daily Persistent Headache With Migrainous Features
TLDR
The experience suggests that ONS is not effective in the treatment of NDPH with migrainous features even in centers with experience in treating chronic migraine with ONS.
New daily persistent headache in children and adults
  • K. Mack
  • Medicine
    Current pain and headache reports
  • 2009
TLDR
The epidemiology, comorbid symptoms, evaluation, and treatment of new daily persistent headache are discussed.
CSF TNFα Has Not Been Shown to be Elevated in Headache Patients
TLDR
The Rozen and Swiden paper does not establish that CSF TNFα is elevated in subjects with headaches as there was not reference value on which to base such a statement, and the question as to the relative level of TNF α in CSF of subjects with various types of headache remains to be determined.
Biomarkers Associated With Migraine and Their Potential Role in Migraine Management
The focus of this review is to review potential diagnostic and therapeutic biomarkers associated with migraine.
New Daily Persistent Headache and Potential New Therapeutic Agents
TLDR
The clinical features, differential diagnosis and potential new therapeutic agents will be discussed and different subtypes and heterogeneity in presentation will be highlighted.
Reduction in high blood tumor necrosis factor-alpha levels after manipulative therapy in 2 cervicogenic headache patients.
TLDR
Two patients with whiplash injury and disk herniation developed CHA associated with very high TNF-alpha levels, and after manipulative therapy, these patients became symptom-free, and their TNF -alpha levels decreased substantially.
Post-infectious new daily persistent headache may respond to intravenous methylprednisolone
TLDR
It is concluded that NDPH-like headache may occur as a post infectious process following a recent infection.
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