Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.

  title={Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.},
  author={Yuemang Yao and C. M. Clark and John Q. Trojanowski and Virginia M-Y Lee and Domenico Pratic{\`o}},
  journal={Annals of neurology},
  volume={58 4},
The 12/15 lipoxygenase (12/15LOX) enzyme is increased in pathologically affected frontal and temporal regions of Alzheimer's disease (AD) brains compared with controls. Herein, we measured 12(S)-HETE and 15(S)-HETE levels, products of 12/15LOX, in cerebrospinal fluid (CSF) of normal individuals, subjects with mild cognitive impairment (MCI) and AD. Compared with controls, there was a significant increase of both metabolites in CSF from AD and MCI, which correlated with lipid peroxidation and… CONTINUE READING
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