Elevated urinary thioether excretion among bidi rollers exposed occupationally to processed tobacco

@article{Govekar1992ElevatedUT,
  title={Elevated urinary thioether excretion among bidi rollers exposed occupationally to processed tobacco},
  author={R. Govekar and R. Bhisey},
  journal={International Archives of Occupational and Environmental Health},
  year={1992},
  volume={64},
  pages={101-104}
}
  • R. Govekar, R. Bhisey
  • Published 1992
  • Medicine
  • International Archives of Occupational and Environmental Health
SummaryManufacture of bidis — the Indian version of cigarettes — is one of the largest cottage industries in India. Bidi rollers handle 225–450 g of bidi tobacco per day and inhale tobacco dust and volatile components present in the work environment. Since tobacco is known to be mutagenic and carcinogenic, urinary cotinine was estimated in bidi rollers and control subjects as an index of tobacco-specific exposure while the concentration of urinary thioethers was determined to ascertain exposure… Expand
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[Smokeless tobacco].
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Information concerning the potential hazards of smokeless tobacco products should be incorporated into educational programmes to discourage its use and to help users to quit. Expand
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The smokers had an increased excretion of thioethers into the urine when compared with the nonsmokers, and the individual variation in the group of low-tar cigarette smokers did not markedly differ from theindividual variation of medium- tar cigarette smokers. Expand
Urinary mercapturic acid excretion as a biological parameter of exposure to alkylating agents
TLDR
Mercapturic acid derivatives or other thioethers can be considered as the endproducts of the metabolic detoxification of possibly alkylating agents and their appearance in the urine can be used as an indicator of exposure of the organism to such toxic compounds. Expand
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The thiols in the morning urine of 224 employees of a chemical plant were determined after alkaline hydrolysis of all urinary thioethers. The highest thioether excretion was found in rubber workersExpand
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TLDR
This paper critically reviews the suitability of the urinary thioether assay as a method for the detection of exposure to electrophilic agents or their precursors and suggests its greatest value appears to lie in its signal function. Expand
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  • International archives of occupational and environmental health
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TLDR
The extraction procedure and the addition of the reagent were found to be critical steps, whereas the crude urine samples were comparatively stable during storage at −20°C, and diet was found to been the most important factor. Expand
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TLDR
The urinary excretion of thioether decreased after one month's exposure and increased thereafter up to five months, informative of exposure to alkylating agents only after several months from starting work. Expand
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TLDR
The results show a higher frequency of chromosome aberrations and a higher excretion of urinary thioethers in smokers as compared to non-smokers, however, linear regression between these parameters was not statistically significant. Expand
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TLDR
The present study indicates that workers employed in the bidi industry are exposed to potentially mutagenic and genotoxic chemicals in the course of their occupation. Expand
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TLDR
Chromatograms of the urines suggest the presence of hydroxycotinine and desmethylcotinines and related Koenig positive components and lead to the conclusion that cotinine plays an important role as intermediate in nicotine metabolism. Expand
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