Elevated urinary plasmin activity resistant to alpha2-antiplasmin in acute poststreptococcal glomerulonephritis.

@article{Oda2008ElevatedUP,
  title={Elevated urinary plasmin activity resistant to alpha2-antiplasmin in acute poststreptococcal glomerulonephritis.},
  author={Takashi Oda and Kikuko Tamura and Nobuyuki Yoshizawa and Tetsuzo Sugisaki and Koichi Matsumoto and Motoshi Hattori and Toshihiro Sawai and Tamehachi Namikoshi and Muneharu Yamada and Yuichi Kikuchi and Shigenobu Suzuki and Soichiro Miura},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2008},
  volume={23 7},
  pages={
          2254-9
        }
}
  • T. Oda, K. Tamura, +9 authors S. Miura
  • Published 1 July 2008
  • Medicine, Biology
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND A pathogenic role of intraglomerular plasmin bound to nephritogenic antigen (nephritis-associated plasmin receptor, NAPlr) and resistant to physiologic inhibitors such as alpha(2)-antiplasmin (alpha(2)-AP) has recently been proposed in acute poststreptococcal glomerulonephritis (APSGN). To confirm this concept, we analysed the urinary profile of plasmin cascade in APSGN patients. METHODS Urine samples from 10 patients with APSGN, 12 patients with IgA nephropathy (IgAN), 10 patients… 
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12 Citations
Background Citations
4
Methods Citations
2
Results Citations
1

12 Citations

Citation Type

Citation Type

The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection
TLDR
Data suggest that NAPlr has a direct, nonimmunologic function as a plasmin receptor and may contribute to the pathogenesis of APSGN by maintaining plAsmin activity.
Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis.
Post-Streptococcal Glomerulonephritis
TLDR
Studies in aboriginal communities indicate that patients with a history of APSGN have a higher incidence of albuminuria, and that APS GN represents a risk factor for the subsequent development of chronic renal failure, if associated with diabetes and obesity.
Role of tubulointerstitial plasmin in the progression of IgA nephropathy
TLDR
Data suggest that TI plasmin is associated with TI inflammation leading to renal fibrosis, and can cause the decline in renal function seen in patients with IgAN, and reducing plasmine in situ may be a promising therapeutic approach slowing renal fibrogenesis and improving renal function.
Acute post-streptococcal glomerulonephritis – immune-mediated acute kidney injury – case report and literature review
TLDR
The existing knowledge on APSGN is summarized with particular emphasis on the immunological mechanisms of the disease, and the proposed immunological pathway leading to glomerular injury is discussed.
Acute post-streptococcal glomerulonephritis: analysis of the pathogenesis
TLDR
The mechanisms reported for the APSGN pathogenesis, the interactions of streptococcal products with renal cells and leukocytes, the possible effects of different nephritogenic antigens in the renal environment and the possibility that APS GN is not just due to a single strePTococcal antigen and its antibody are described.
Post-streptococcal glomerulonephritis: Immunopathological aspects and perspectives for in silico experiments
TLDR
The extension of AutoSimmune to include important environments such as the kidney tissue as well as agents representing S. pyogenes and also the complement system provides an important basis for the development of the proposed computational approach for the disease scrutiny.
Mechanisms of renal NaCl retention in proteinuric disease
TLDR
Human lymphocytes may be used to uncover the effect of urine plasmin on amiloride‐ and aprotinin‐sensitive inward currents and contribute to inappropriate NaCl retention and oedema in acute proteinuric conditions and to hypertension in diseases with chronic microalbuminuria/proteinuria.
Acute Postinfectious Glomerulonephritis in Children
TLDR
The development of glomerular inflammation and severity, as well as the progression to chronic renal lesions, depends, on a large measure, on the duration of antigen exposure and the host’s capacity to remove the deposited complexes.
Diagnostic urinary proteome profile for immunoglobulin a nephropathy.
TLDR
This proteome profile could be utilized in the diagnosis of IgA nephropathy in addition to providing a noninvasive diagnostic tool, it may shed light on the pathogenic pathways of inflammatory response and complement system.
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References

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TLDR
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TLDR
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TLDR
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  • T. Oda, N. Yoshizawa, +4 authors S. Miura
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2007
TLDR
The results suggest that apoptosis exists in the glomerulus in patients with APSGN from the early to the late stages of the disease and contributes to the resolution of glomerular hypercellularity.
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