Elevated urinary leukotriene E4 in chronic lung disease of extreme prematurity.

@article{Davidson1995ElevatedUL,
  title={Elevated urinary leukotriene E4 in chronic lung disease of extreme prematurity.},
  author={Dennis R Davidson and Denise Drafta and Barbara Wilkens},
  journal={American journal of respiratory and critical care medicine},
  year={1995},
  volume={151 3 Pt 1},
  pages={
          841-5
        }
}
We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CLD (n = 26, abnormal chest X-ray, supplemental O2 requirement +/- ventilator). Urinary LTE4 levels were significantly elevated in CLD compared with the control group (288 +/- 92… CONTINUE READING
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