Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.

@article{Mazzali2001ElevatedUA,
  title={Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.},
  author={Marilda Mazzali and Jeremy Hughes and Young Gon Kim and Jonathan Ashley Jefferson and Duk Hee Kang and Katherine L Gordon and Hui Y Lan and S D Kivlighn and Richard J Johnson},
  journal={Hypertension},
  year={2001},
  volume={38 5},
  pages={1101-6}
}
An elevation in circulating serum uric acid is strongly associated with the development of hypertension and renal disease, but whether uric acid has a causal role or whether it simply indicates patients at risk for these complications remains controversial. We tested the hypothesis that uric acid may have a causal role in the development of hypertension and renal disease by examining the effects of mild hyperuricemia in rats. Mild hyperuricemia was induced in rats by providing a uricase… CONTINUE READING
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