Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients

@inproceedings{Bache2009ElevatedTA,
  title={Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients},
  author={Matthias Bache and Matthias Kappler and Henri Wichmann and Swetlana Rot and Antje Hahnel and Thomas Greither and Harun M. Said and Matthias Kotzsch and Peter W{\"u}rl and Helge Taubert and Dirk Vordermark},
  booktitle={BMC Cancer},
  year={2009}
}
Osteopontin (OPN) overexpression is correlated with a poor prognosis for tumor patients. However, only a few studies investigated the prognostic impact of expression of OPN in soft tissue sarcomas (STS) yet. This study is based on tumor and serum samples from 93 adult STS patients. We investigated OPN protein levels in serum (n = 86) and tumor tissue (n = 80) by ELISA and OPN mRNA levels in tumor tissue (n = 68) by quantitative real-time PCR. No correlation was found between OPN levels in serum… CONTINUE READING

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