Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety

@article{Harris2003ElevatedSD,
  title={Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety},
  author={Andrew C Harris and Jonathan C. Gewirtz},
  journal={Psychopharmacology},
  year={2003},
  volume={171},
  pages={140-147}
}
An elevated startle response has been observed in humans and animals during withdrawal from multiple substances of abuse, a phenomenon thought to reflect the anxiogenic effects of withdrawal. Although anxiety is a common symptom of opiate withdrawal, few studies have examined the effects of morphine withdrawal on acoustic startle. To develop a procedure for assessing opiate dependence through measurement of the startle reflex in rats. The effects of opiate withdrawal on startle were evaluated… CONTINUE READING

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