Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity.

@article{Yoo1996ElevatedSB,
  title={Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity.},
  author={Hwan Soo Yoo and William P. Norred and Jency L. Showker and Ronald T. Riley},
  journal={Toxicology and applied pharmacology},
  year={1996},
  volume={138 2},
  pages={211-8}
}
Fumonisin B1 is an inhibitor of ceramide synthase, a key enzyme in de novo sphingolipid biosynthesis and reacylation of free sphingosine. The purpose of this study was to determine the contribution of increased intracellular free sphinganine and decreased complex sphingolipids on cell growth and cell death induced by fumonisin B1 in pig kidney LLC-PK1 cells. Fumonisin B1 caused an increase in intracellular free sphinganine which preceded depletion of complex sphingolipids, inhibition of cell… CONTINUE READING
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