Elevated soluble CD30 correlates with development of bronchiolitis obliterans syndrome following lung transplantation.

@article{Fields2006ElevatedSC,
  title={Elevated soluble CD30 correlates with development of bronchiolitis obliterans syndrome following lung transplantation.},
  author={Ryan Courtney Fields and Ankit Bharat and Nancy Steward and Aviva A Aloush and Brian Meyers and Elbert P. Trulock and William C. Chapman and G. Alexander Patterson and Thalachallour Mohanakumar},
  journal={Transplantation},
  year={2006},
  volume={82 12},
  pages={1596-601}
}
BACKGROUND The long-term function of lung transplants is limited by chronic rejection (bronchiolitis obliterans syndrome, BOS). Due to lack of specific markers, BOS is diagnosed clinically. Because there is strong evidence that alloimmunity plays a significant role in the pathogenesis of BOS, we investigated whether soluble CD30 (sCD30), a T-cell activation marker, would correlate with BOS. METHODS Sera collected serially from BOS+ (n = 20) and matched BOS- (n = 20) lung transplant (LT… CONTINUE READING
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