Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic

@article{Burgdorf1977ElevatedSC,
  title={Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic},
  author={Walter H. C. Burgdorf and Karen Kurvink and Jaroslav Cervenka},
  journal={Human Genetics},
  year={1977},
  volume={36},
  pages={69-72}
}
An elevated sister chromatid exchange (SCE) rate was found in the lymphocytes of six patients treated with arsenic. All had stigmata of arsenic use as well as biopsy-proven skin cancers. The arsenic exposed patients had a mean of 14.00 SCE/mitosis while 44 normal controls had a mean of 5.8 SCE/mitosis. Chromosome breakage analysis revealed no difference between the two groups. SCE rate has been shown to be elevated in a variety of systems where cell cultures or experimental animals were exposed… CONTINUE READING

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spermatogonia as a new test for environmental mutagens

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