Elevated serum tumour necrosis factor-alpha levels can contribute to the insulin resistance in Type II (non-insulin-dependent) diabetes and in obesity

@article{Winkler1998ElevatedST,
  title={Elevated serum tumour necrosis factor-alpha levels can contribute to the insulin resistance in Type II (non-insulin-dependent) diabetes and in obesity},
  author={G{\'a}bor Winkler and Ferenc Salamon and D{\'a}niel Salamon and G{\'a}bor Speer and Korn{\'e}l Simon and K{\'a}roly Cseh},
  journal={Diabetologia},
  year={1998},
  volume={41},
  pages={860-861}
}
Dear Sir, Tumour necrosis factor alpha (TNF-a) may play a role in the pathophysiology of obesity and also in the obesity-diabetes link [1]. The overexpression of the cytokine has been demonstrated in the adipose tissue of different rodent genetic models of obesity [2]. This overexpression of TNF-a led to the downregulation of the signal transduction of insulin receptor via the increased serin phosphorilation of the insulin receptor substrate (IRS)-1 turning it to an inhibitor of the receptor [3… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 10 references

Circulating tumor necrosis factor alpha is elevated in male but not in female patients with type II diabetes mellitus.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 1997
View 1 Excerpt

Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 1996
View 1 Excerpt

Similar Papers

Loading similar papers…