Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy.

@article{Schwartzkopff2002ElevatedSM,
  title={Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy.},
  author={Bodo Schwartzkopff and Michael Fassbach and Beate Pelzer and Michael Brehm and Bodo Eckehard Strauer},
  journal={European journal of heart failure},
  year={2002},
  volume={4 4},
  pages={439-4}
}
BACKGROUND AND AIMS Left ventricular (LV) dilation and myocardial remodelling are hallmarks of heart failure in idiopathic dilated cardiomyopathy (DCM). Interstitial collagen is essential for LV integrity and function while degradation of collagen by collagenases, especially matrix-metalloproteinases (MMPs), are suggested to contribute to ventricular dilation. In the present study, serological markers of collagen metabolism were investigated. METHODS AND RESULTS Serum levels of MMP-1 and its… CONTINUE READING