Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

@article{Hussain1996ElevatedSL,
  title={Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM},
  author={Munther Jaffar Hussain and Mark Peakman and Harald Gallati and Sunny SL Lo and Mohammed Hawa and Gian Carlo Viberti and Peter J. Watkins and R David Leslie and Professor D. Vergani},
  journal={Diabetologia},
  year={1996},
  volume={39},
  pages={60-69}
}
To determine whether cytokines could have a role in the development of insulin-dependent diabetes mellitus (IDDM), we measured serum levels of cytokines derived from T helper 1 (interleukin-2 and interferon-γ), T helper 2 (interleukin-4 and inter-leukin-10) lymphocytes and macrophages (tumour necrosis factor-α, interleukin-1 α and interleukin-1 Β) in patients before and after the onset of IDDM. Recently diagnosed IDDM patients had significantly higher levels of interleukin-2, interferon… CONTINUE READING
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