Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma.

@article{Schmidt2006ElevatedSL,
  title={Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma.},
  author={Henrik Schmidt and Julia Sidenius Johansen and Julie Gehl and Poul Flemming Geertsen and Kirsten Fode and Hans von der Maase},
  journal={Cancer},
  year={2006},
  volume={106 5},
  pages={1130-9}
}
BACKGROUND YKL-40 is a growth factor for connective tissue cells and stimulates migration of endothelial cells. Cancer cells, macrophages, and neutrophils secrete YKL-40. Its function in cancer is unknown. High serum YKL-40 levels have been associated with a poor prognosis in patients with several solid tumors. The prognostic impact of serum YKL-40 in metastatic melanoma was evaluated. METHODS YKL-40 was measured in serial serum samples from 110 patients with metastatic melanoma obtained… CONTINUE READING

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