Elevated serum level and gene polymorphisms of TGF-beta1 in gastric cancer.

@article{Li2008ElevatedSL,
  title={Elevated serum level and gene polymorphisms of TGF-beta1 in gastric cancer.},
  author={Xue Li and Zhi-Chao Yue and Yun-yan Zhang and Jing Bai and Xiang-ning Meng and Jing-shu Geng and Song-bin Fu},
  journal={Journal of clinical laboratory analysis},
  year={2008},
  volume={22 3},
  pages={164-71}
}
Transforming growth factor (TGF)-beta1, as a candidate tumor marker, is currently of interest. In this study, serum TGF-beta1 levels in gastric cancer (GC) patients and healthy volunteers were measured using enzyme-linked immunosorbent assay (ELISA). In addition, single nucleotide polymorphisms (SNPs) of the TGF-beta1 gene at codon 10 and codon 25 were identified by means of amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and sequence analysis. Our results… CONTINUE READING

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In addition , single nucleotide polymorphisms ( SNPs ) of the TGF - beta1 gene at codon 10 and codon 25 were identified by means of amplification refractory mutation system - polymerase chain reaction ( ARMS - PCR ) and sequence analysis .
In addition , single nucleotide polymorphisms ( SNPs ) of the TGF - beta1 gene at codon 10 and codon 25 were identified by means of amplification refractory mutation system - polymerase chain reaction ( ARMS - PCR ) and sequence analysis .
Our evidence suggested that serum concentration of TGF - beta1 might be a novel tumor marker for GC and the polymorphisms of TGF - beta1 gene did not play a role as a determinant of serum TGF - beta1 concentration or as a genetic risk factor in the gastric carcinogenesis and progression .
In addition , single nucleotide polymorphisms ( SNPs ) of the TGF - beta1 gene at codon 10 and codon 25 were identified by means of amplification refractory mutation system - polymerase chain reaction ( ARMS - PCR ) and sequence analysis .
Our evidence suggested that serum concentration of TGF - beta1 might be a novel tumor marker for GC and the polymorphisms of TGF - beta1 gene did not play a role as a determinant of serum TGF - beta1 concentration or as a genetic risk factor in the gastric carcinogenesis and progression .
Our evidence suggested that serum concentration of TGF - beta1 might be a novel tumor marker for GC and the polymorphisms of TGF - beta1 gene did not play a role as a determinant of serum TGF - beta1 concentration or as a genetic risk factor in the gastric carcinogenesis and progression .
In addition , single nucleotide polymorphisms ( SNPs ) of the TGF - beta1 gene at codon 10 and codon 25 were identified by means of amplification refractory mutation system - polymerase chain reaction ( ARMS - PCR ) and sequence analysis .
In addition , single nucleotide polymorphisms ( SNPs ) of the TGF - beta1 gene at codon 10 and codon 25 were identified by means of amplification refractory mutation system - polymerase chain reaction ( ARMS - PCR ) and sequence analysis .
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