Elevated serum heparanase-1 levels in patients with pancreatic carcinoma are associated with poor survival.

@article{Quiros2006ElevatedSH,
  title={Elevated serum heparanase-1 levels in patients with pancreatic carcinoma are associated with poor survival.},
  author={Roderick M. Quiros and Geetha Rao and Janet M. D. Plate and Jules E. Harris and Gregory J. Brunn and Jeffrey L Platt and Paolo Gattuso and Richard Allen Prinz and Xiulong Xu},
  journal={Cancer},
  year={2006},
  volume={106 3},
  pages={
          532-40
        }
}
BACKGROUND It has previously been shown that heparanase-1 (HPR1), an endoglycosidase, is up-regulated in pancreatic carcinoma. The purpose of this study was to test whether serum HPR1 levels in pancreatic carcinoma patients are elevated, and whether higher serum HPR1 levels are associated with a shortened survival. METHODS Serum HPR1 levels in 40 healthy donors, 31 pancreatic carcinoma patients, and 11 patients treated with gemcitabine were measured by a novel enzyme-linked immunoadsorbent… CONTINUE READING
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