Elevated serum gastrin levels in Jervell and Lange-Nielsen syndrome: a marker of severe KCNQ1 dysfunction?

@article{Rice2011ElevatedSG,
  title={Elevated serum gastrin levels in Jervell and Lange-Nielsen syndrome: a marker of severe KCNQ1 dysfunction?},
  author={Kathryn S Rice and Graeme Dickson and Mark Lane and Jackie Robyn Crawford and Seo-Kyung Chung and Mark Ian Rees and Andrew N Shelling and Donald R. Love and Jonathan R Skinner},
  journal={Heart rhythm},
  year={2011},
  volume={8 4},
  pages={551-4}
}
BACKGROUND The potassium channel I(Ks), which is encoded by the KCNQ1 gene, is expressed in organ systems including the inner ear, kidneys, lungs, intestine, and stomach in addition to the heart. Increasing evidence indicates that I(Ks) in the stomach plays an essential role in enabling gastric acid production. It is not known whether gastric acid production is disordered in patients with long QT type 1. Serum gastrin levels become elevated in subjects with disordered gastric acid production… CONTINUE READING

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