Elevated serum cytokine levels in mesothelioma patients who have undergone pleurectomy or extrapleural pneumonectomy and adjuvant intraoperative photodynamic therapy.

@article{Yom2003ElevatedSC,
  title={Elevated serum cytokine levels in mesothelioma patients who have undergone pleurectomy or extrapleural pneumonectomy and adjuvant intraoperative photodynamic therapy.},
  author={Sue S Yom and Theresa M. Busch and Joseph S. Friedberg and E. Paul Wileyto and Deborah Gorman Smith and Eli J. Glatstein and Stephen M. Hahn},
  journal={Photochemistry and photobiology},
  year={2003},
  volume={78 1},
  pages={75-81}
}
Patients treated on a Phase-I clinical trial of photodynamic therapy (PDT) developed a systemic capillary leak syndrome that constituted the dose-limiting toxicity. We examined serum samples from patients treated at the maximally tolerated dose level for evidence of a systemic, cytokine-mediated inflammatory response. Patients underwent pleurectomy or extrapleural pneumonectomy (EPP) followed by intraoperative PDT of the thorax using Foscan at a dose of 0.1 mg/kg 6 days before surgery and 652… CONTINUE READING

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