Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis.

@article{Soldan2001ElevatedSA,
  title={Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis.},
  author={Samantha S. Soldan and Anna Fogdell-Hahn and Meghan B. Brennan and Barbara B. Mittleman and Clara Ballerini and Luca Massacesi and Tsukasa Seya and Henry F. McFarland and Steven Jacobson},
  journal={Annals of neurology},
  year={2001},
  volume={50 4},
  pages={486-93}
}
Membrane cofactor protein (CD46) is a member of a family of glycoproteins that are regulators of complement and prevent activation of complement on autologous cells. Recently, CD46 has been identified as the cellular receptor for human herpesvirus Type 6 (HHV-6). Elevated levels of soluble CD46 have been described in several autoimmune disorders, and may be implicated in the pathogenesis of these diseases. As several reports have supported an association of HHV-6 and multiple sclerosis, it was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…