Elevated rates of early discontinuation from pharmacotherapy trials in alcoholics and drug abusers.

@article{Kranzler1996ElevatedRO,
  title={Elevated rates of early discontinuation from pharmacotherapy trials in alcoholics and drug abusers.},
  author={Henry R. Kranzler and Red{\'i}n Escobar and Dae Keun Lee and Erwin Meza},
  journal={Alcoholism, clinical and experimental research},
  year={1996},
  volume={20 1},
  pages={
          16-20
        }
}
The failure of subjects to complete clinical trials is a common problem with important implications for the interpretation of study results. Although a substantial literature exists on the high prevalence of premature termination from psychiatric and substance abuse treatment setting, there has been little attention paid to early discontinuation in clinical trials. There is evidence that the presence of substance abuse predicts higher rates of early discontinuation. This, combined with a recent… CONTINUE READING

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