Elevated production of salivary nitric oxide in oral mucosal diseases.

  title={Elevated production of salivary nitric oxide in oral mucosal diseases.},
  author={Masaru Ohashi and Masayasu Iwase and Masao Nagumo},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  volume={28 8},
Nitric oxide (NO) is known to play an important role in biological systems. In this study, we measured levels of NO in the saliva of 39 patients with oral mucosal diseases: 21 had oral lichen planus (OLP) and 18 had recurrent aphthous ulceration (RAU). NO was assayed using the Griess reagent, which measures nitrite (NO2), the byproduct of NO. NO2 was detected in all tested samples, and levels in the saliva of patients were significantly increased relative to those of healthy subjects. We also… CONTINUE READING